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This Health Alert Network Advisory is from the CDC  regarding a 

CDC and Louisiana Department of Health (LDH) Update: Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania. 

Please see the message below and share/distribute any/all of this information to all partners and stakeholders as deemed appropriate.

CDC and Louisiana Department of Health (LDH) Update: Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments in the United States about two confirmed outbreaks of Marburg virus disease (MVD)—one in Equatorial Guinea and one in Tanzania. Currently, there is no evidence to suggest that these two outbreaks are related; most experts agree that these represent two independent animal-to-human spillover events. To date, 

no confirmed cases of MVD related to these outbreaks have been reported in the United States or other countries outside Equatorial Guinea and Tanzania 

. This Health Advisory provides information about these outbreaks to increase awareness of the risk of imported cases in the United States. It also summarizes CDC’s recommendations for case identification, testing, and clinical laboratory biosafety considerations in the United States.

 is a rare but highly fatal viral hemorrhagic fever caused by two zoonotic viruses, Marburg virus and Ravn virus, that are closely related to ebolaviruses within family 

 were reported in Equatorial Guinea and Tanzania. These outbreaks mark the first time that Marburg virus has been identified in either Equatorial Guinea or Tanzania, though the virus has been identified previously in neighboring countries and the reservoir, the Egyptian fruit bat, is known to be present in both countries. Available information suggests that these outbreaks may have originated separately in each country. To date, there is no evidence that these two outbreaks are epidemiologically linked. Viral genetic sequencing from Tanzania is in process; these results, along with sequence data available from Equatorial Guinea, will further inform whether the outbreaks emerged separately through distinct animal-to-human spillover events.

A person with MVD is not contagious until 

 may include fever, headache, muscle and joint pain, fatigue, loss of appetite, gastrointestinal symptoms, or unexplained bleeding. 

(through broken skin or mucous membranes) with the blood or other body fluids (including urine, saliva, sweat, feces, vomit, breast milk, amniotic fluid, or semen) of a person who is sick with or has died from MVD, with the body fluids of infected animals, or with needles or other fomites that are contaminated with the virus. Marburg virus is 

There is currently no Food and Drug Administration (FDA)-approved vaccine or treatment for MVD. In the absence of early diagnosis and appropriate supportive care, MVD has a high mortality rate of 23%–%With early intensive supportive care and fluid replacement, mortality rates may be lower.

On February 7, 2023, the Ministry of Health and Social Welfare of Equatorial Guinea reported a cluster of deaths suspected to be caused by a viral hemorrhagic fever. The deaths occurred in early January among people in two villages in the district of Nsok-Nsomo, in the eastern province of Kié-Ntem, Río Muni Region.

On February 12, 2023, clinical samples were collected from known contacts of the decedents and sent to the Institute Pasteur in Dakar, Senegal, where one sample was confirmed positive for Marburg virus by real-time polymerase chain reaction (RT-PCR). This index (first confirmed) patient presented with fever, vomiting, bloody diarrhea, and convulsions and died the same day. This patient appears to be epidemiologically linked to four deceased community members from one of the affected villages in Nsok-Nsomo district.

On March 13, 2023, two additional samples collected from people in Kié-Ntem province tested positive for Marburg virus by RT-PCR performed at a CDC-supported field laboratory at the Regional Hospital of Ebibeyin. As of April 5, 2023, 14 laboratory-confirmed MVD cases have been identified from five districts across four provinces in Equatorial Guinea. Ten of these cases were fatal. There are no known epidemiologic links between patients in one province, Centre Sur. This, taken together with the wide geographic spread of the outbreak within the country, suggests that there may be undetected community spread of the virus in the country. All suspect cases in nearby surrounding countries have been confirmed negative to date.

On March 21, 2023, the Ministry of Health of Tanzania announced an MVD outbreak. The announcement followed the identification of Marburg virus by RT-PCR in clinical samples collected from patients in several villages in the northwest Kagera region. As of April 5, 2023, 8 laboratory-confirmed MVD cases have been reported. Five of these infections were fatal. Based on currently available information, all these individuals with MVD are from Kagera Region in Tanzania and appear to be epidemiologically linked.

Currently, the risk of MVD in the United States is low; however, clinicians should be aware of the potential for imported cases. It is important to systematically assess patients for the possibility of viral hemorrhagic fevers (including MVD or Ebola disease) through a 

. Early identification of MVD or other viral hemorrhagic fevers is important for providing appropriate and prompt patient care and preventing the spread of infection. Recent presence in Equatorial Guinea or Tanzania should not be a reason to defer 

or other measures necessary for standard patient care.

MVD should be included as a differential diagnosis for an ill person with history of a 

concerning exposure while in a MVD affected area

 (e.g., contact with a symptomatic person with suspected or confirmed MVD or an unknown illness; attending/participating in a funeral; visiting or working in a healthcare facility; having contact with bats or non-human primates; working or spending time in a mine/cave) within 21 days before symptom onset and who have clinical symptoms such as fever, headache, muscle and joint pain, fatigue, loss of appetite, gastrointestinal symptoms, or unexplained bleeding. Alternative diagnoses such as 

 , COVID-19, influenza, or common causes of gastrointestinal and febrile illnesses in a patient with recent international travel should be considered, evaluated, and managed appropriately. Additionally, patients with a Marburg virus infection may present with concurrent infections (e.g., co-infection with malaria) and the possibility of a concurrent infection should be considered if a patient has a clinical and epidemiologic history compatible with MVD.

If a patient is determined to meet criteria for Marburg virus testing, the patient is considered a suspect case of MVD and should be managed under isolation precautions until receiving a negative Marburg virus test result on a sample collected > 72 hours after symptom onset. 

 to monitor the patient’s clinical status and diagnostic testing for other potential causes of the patient’s illness should be pursued while Marburg virus testing is underway. Marburg virus diagnostic testing should not be delayed while awaiting results of other diagnostic testing.

Clinicians with concerns about a patient with 

 should immediately contact the Infectious Disease Epidemiology (IDEpi) 24/7 clinician hotline: 800-256-2748. If a diagnosis of MVD is considered, clinical teams should coordinate with LDH and CDC to ensure appropriate precautions are taken to help prevent potential spread.

Clinicians caring for patients with planned travel to an MVD outbreak affected area can counsel their patients on ways to 

 during their travel. This includes avoiding contact with blood and body fluids (or materials possibly contaminated with blood and body fluids) of people who are sick; funeral or burial practices that involve touching the body of someone who died from suspected or confirmed MVD; or contact with fruit bats and nonhuman primates and areas known to be inhabited by fruit bats (such as mines or caves).

combination of infection prevention and control measures

 to prevent transmission of MVD. These infection prevention and control measures include personal protective equipment (PPE), patient placement, and patient care considerations. If MVD is suspected, patients should be isolated in a private room with a private bathroom or covered bedside toilet. Healthcare personnel should follow the same 

infection prevention and control measures as recommended for Ebola disease

recommended personal protective equipment (PPE)

 and limiting the number of personnel who enter the room for clinical evaluation and management.

Healthcare personnel can be exposed through contact with a patient’s body fluids, contaminated medical supplies and equipment, or contaminated environmental surfaces. Splashes to unprotected mucous membranes (e.g., the eyes, nose, or mouth) are particularly hazardous. Procedures that can increase environmental contamination with infectious material, involve handling of potentially contaminated needles or other sharps, or create aerosols should be minimized. Separate 

 is available for managing clinically stable and clinically unstable patients.

Testing for Marburg virus and other causes of viral hemorrhagic fevers is available at CDC (Atlanta, Georgia) and within the 

 . To date, 32 geographically diverse LRN laboratories and 8 Regional Emerging Special Pathogen Treatment Centers can test using the 

 , with several more LRN laboratories working toward building testing capability. The Warrior Panel can detect marburgviruses (Marburg and Ravn viruses) and ebolaviruses (Ebola, Sudan, Tai Forest, Bundibugyo, and Reston viruses) in addition to other high-consequence pathogens.

CDC has issued travel health notices for 

 and could consider engaging traveler health clinics or other clinical and public health partners to increase awareness on MVD. There are no direct commercial flights from Equatorial Guinea or Tanzania to the United States and the number of travelers arriving in the United States from either country is low. Currently, no enhanced domestic travel measures are recommended, as the overall risk in the United States is considered low at this time

Early symptoms associated with MVD are similar to 

 associated with fever in returning travelers. MVD is rare; patients with suspected symptoms should be asked a detailed travel history and should be tested for other conditions and treated accordingly. Clinical laboratories can 

 for patients with suspected MVD by following 

Standard Precautions for All Patient Care

Universal Precautions for Preventing Transmission of Bloodborne Infections

Under the Occupational Safety and Health Administration’s (OSHA’s) Bloodborne Pathogens Standard, laboratories handling blood and body fluids must have a written 

 in place to eliminate or minimize employees’ risk of exposure to blood or other potentially infectious materials. 

 should be available and staff should be trained to properly put on and take off (don and doff) their PPE. If a facility does not have the appropriate risk mitigation capabilities, the specimen should be forwarded to another facility that does.